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The final exam will cover lectures and labs from the lecture on Genetic Progression in Gastrointestinal Neoplasia to the end of the course. The following is a recommended list of reading. Articles marked by an asterisk are optional reading. The exam will emphasize the materials that were specifically presented or discussed in lectures.

Gastrointestinal Neoplasia

Cotran, et al. "Tumors of Colon and Rectum." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 827-835. ISBN: 9780721673356 .

Houlston, R. S. "What We Could do Now: Molecular Pathology of Colorectal Cancer." Mol Pathol 54, no. 4 (Aug 2001): 206-14.

Peltomaki, P. "Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer." J Clin Oncol 21, no. 6 (Mar 15, 2003): 1174-9.

Cervical Neoplasia

Cotran, et al. "Cervical Intraepithelial Neoplasia and Cancer." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1049-1053. ISBN: 9780721673356 .

*zur Hausen, H. "Papillomaviruses and Cancer: From Basic Studies to Clinical Application." Nat Rev Cancer 2, no. 5 (May 2002): 342-50.

Lymphoid Neoplasms

Cotran, et al. "Lymphoid Neoplasms." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 651-658. ISBN: 9780721673356 . (all)

———. "AML." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 675-678. ISBN: 9780721673356 .

*Shaffer, A. L., A. Rosenwald, and L. M. Staudt. "Lymphoid Malignancies: The Dark Side of B-cell Differentiation." Nat Rev Immunol 2, no. 12 (Dec 2002): 920-32.

Sickle Cell Disease

Cotran, et al. "Sickle Cell Disease." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 611-615. ISBN: 9780721673356.

Steinberg, M. H., and C. Brugnara. "Pathophysiological-based Approaches to Treatment of Sickle Cell Disease." Annu Rev Med 54 (2003): 89-112. (Epub Dec 03, 2001).

Neurodegenerative Diseases

Cotran, et al. "Alzheimer Disease." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1329-1333. ISBN: 9780721673356.

———. "Parkinsonism." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1333-1334. ISBN: 9780721673356 .

Taylor, J. P., J. Hardy, and K. H. Fischbeck. "Toxic Proteins in Neurodegenerative Disease." Science 296, no. 5575 (Jun 14, 2002): 1991-5.

CNS Neoplasia

Cotran, et al. "CNS Tumors." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1343-1348. ISBN: 9780721673356 .

Louis, D. N., S. L. Pomeroy, and J. G. Cairncross. "Focus on Central Nervous System Neoplasia." Cancer Cell 1, no. 2 (Mar 2002): 125-8.

Louis, D. N., E. C. Holland, and J. G. Cairncross. "Glioma Classification: A Molecular Reappraisal." Am J Pathol 159, no. 3 (Sep 2001): 779-86.

Skeletal Muscle

Cotran, et al. "General Introduction." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1272-1275. ISBN: 9780721673356 .

———. "Diseases of Skeletal Muscle." Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1280-1289. ISBN: 9780721673356 .

Forensic Pathology

*Carey, L., and L. Mitnik. "Trends in DNA Forensic Analysis." Electrophoresis 23, no. 10 (May 2002): 1386-97.

Molecular Cytogenetics

*Wang, N. "Methodologies in Cancer Cytogenetics and Molecular Cytogenetics." Am J Med Genet 115, no. 3 (Oct 30, 2002): 118-24.

DNA Microarrays

Ramaswamy, S., and T. R. Golub. "DNA Microarrays in Clinical Oncology." J Clin Oncol 20, no. 7 (Apr 2002): 1932-41.

Functional Imaging

No Supplementary Reading.

Molecular Imaging

Weissleder, R., and U. Mahmood. "Molecular Imaging." Radiology 219 (2001): 316-333.

Weissleder, R. "Scaling Down Imaging: Molecular Mapping of Cancer in Mice." Nat Rev Cancer 2, no. 1 (Jan 2002): 11-8.

Autopsy

Burton, E. C. "The Autopsy: A Professional Responsibility in Assuring Quality of Care." Am J Med Qual 17, no. 2 (Mar-Apr 2002): 56-60.