| LEC # | TOPICS | READINGS |
|---|---|---|
| I. Principles Of Implant Design (Working Paradigms) | ||
| 1 | Clinical Problems Requiring Implants for Solution | Chapter 1 Outline (PDF) TORA. Chapter 1. |
| 2 | Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices | Chapter 2 Outline (PDF) |
| 3 | The Missing Organ and its Replacement | TORA. Chapter 1. |
| 4 | Criteria for Materials Selection | TORA. Chapter 1. |
| 5 | Tissue Engineering I: Scaffolds | Langer, Robert, and Joseph P. Vacanti. "Tissue Engineering." Science, New Series 260, no. 5110 (May 14, 1993): 920-926. |
| 6 | Tissue Engineering II: Cells and Regulators | |
| 7 | Case Study of Organ Regeneration | TORA. Chapters 6, 7, and 10. Yannas, I. V., et al. "Wound Tissue Can Utilize a Polymeric Template to Synthesize a Functional Extension of Skin." Science, New Series 215, no. 4529 (January 8, 1982): 174-176. |
| II. Design Parameters | ||
| 8 | Design Specifications: Biomaterials Survey | |
| Quiz | ||
| 9 | Biocompatibility: Local and Systemic Effects | |
| 10 | Design Specifications: Tissue Bonding and Modulus Matching | |
| 11 | Degradation of Devices: Natural and Synthetic Polymers |  Spector, Myron. "Biomaterials." Chapter 19 in Plastic Surgery. Vol. 1. Edited by B. M. Achauer, et al. Mosby: St. Louis, 2000. ISBN: 9780815110194. |
| 12 | Biocompatibility: Scar Formation and Contraction | TORA. Chapters 1, 2, and 4. |
| 13 | Degradation of Devices: Corrosion and Wear | |
| 14 | Federal Regulation of Devices I | FDA Guidance for Industry documents: E6 Good Clinical Practice: Consolidated Guidance (PDF) E10 Choice of Control Group and Related Issues in Clinical Trials (PDF) |
| 15 | Oral Presentations of Proposals for Design II | |
| 16 | Federal Regulation of Devices II | What is CE Marking? |
| III. Design Solution In-use | ||
| 17 | Scaffolds for Cartilage Repair | |
| 18 | Implants for Bone | |
| 19 | Implants for Plastic Surgery | |
| 20 | Cardiovascular Prostheses: Heart Valves and Blood Vessels | Mitchell, L. Shannon, and Laura E. Niklason. "Requirements for Growing Tissue-Engineered Vascular Grafts." Cardiovascular Pathology 12 (2003): 59-64. Niklason, L. E., J. Gao, W. M. Abbot, K. K. Hirschi, S. Houser, R. Marini, and R. Langer. "Functional Arteries Grown in Vitro." Science 284 (April 16, 1999): 489-493. Schoen, Frederick J., and Robert J. Levy. "Tissue Heart Valves: Current Challenges and Future Research Perspectives." Founder's Award, 25th Annual Meeting of the Society for Biomaterials, Providence, RI, April 28-May 2, 1999. Rabkin, Elena, and Frederick J. Schoen. "Cardiovascular Tissue Engineering." Cardiovascular Pathology II (2002): 305-317. |
| 21 | Devices for Nerve Regeneration | TORA. Chapter 6. |
| 22 | Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk | |
| 23 | Dental and Otologic Implants | |
| 24 | Other Devices: Spinal Cord, Heart Lung | |
| 25 | Final Oral Presentation of Designs (Mock FDA Panel) | |
Table of Contents
Study Materials
Readings
| When you click the Amazon logo to the left of any citation and purchase the book (or other media) from Amazon.com, MIT OpenCourseWare will receive up to 10% of this purchase and any other purchases you make during that visit. This will not increase the cost of your purchase. Links provided are to the US Amazon site, but you can also support OCW through Amazon sites in other regions. Learn more. |
This page presents various outlines, notes, textbook selections, and journal articles assigned for some class sessions.
TORA = Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer-Verlag, 2001. ISBN: 9780387952147.