| LEC # | TOPICS | KEY DATES |
|---|---|---|
| 1 | Introduction: Dimensions of information available to define the unknown causes of common diseases | |
| 2 | Public health records and estimation of age-specific risk | |
| 3 | Effects of changes in diagnosis, prevention and therapy on historical mortality rates Sources of differences in reported incidence and mortality | PS 1 due |
| 4 | Mathematical models derived from histopathological observations and age-specific mortality/incidence data Examples: lung and colorectal cancers | |
| 5 | Initiation | |
| 6 | Promotion and Progression | Term paper chapter 1 due |
| 7 | Multiparametric Analysis of Colon Cancer | |
| 8 | Multiparametric Analysis of Lung Cancer | PS 3 due |
| 9 | Role of Gender | |
| 10 | Sub-populations at Risk | |
| 11 | National Risk and Community Risk | |
| 12 | Familial Risk Expectations | |
| 13 | Familial Risk Observations | Term paper chapter 2 due |
| 14 | Population Genetics | |
| 15 | Population Genetics (cont.) | |
| 16 | The search for genes carrying mutations conferring risk for common diseases | |
| 17 | The search for genes carrying mutations conferring risk for common diseases (cont.) | |
| 18 | The search for genes carrying mutations conferring risk for common diseases (cont.) | Term paper chapter 3 due |
| 19 | The search for genes carrying mutations conferring risk for common diseases (cont.) | |
| 20 | The search for genes in which mutations of initiation (and promotion, if any) occur in common human cancers | |
| 21 | The origins of somatic and inherited mutations in humans | |
| 22 | The origins of somatic and inherited mutations in humans (cont.) | |
| 23 | Hypotheses that need testing | Term paper chapter 4 due |
| 24 | Evolution, embryogenesis and carcinogenesis (Guest lecturer: Dr. Elena V. Gostjeva) Putting it together: Gostjeva-Thilly cascade model for risk and genesis of common clonal diseases | |
| 25-27 | General discussion and student presentations | Final term paper due |