| LEC # | TOPICS | READINGS |
|---|---|---|
| 1 | Introduction and Principles | |
| 2 | Chemistry/Biochemistry Review | |
| 3 | Overview of Drug Development | Golan. Chapters 48 and 51. |
| 4 | Uptake/Transport/Distribution of Drugs | Golan. pp. 27-33. |
| 5 | Drug Transporters | |
| 6 | Bioethics Seminar | |
| 7 | Drug Transporters (cont.) | |
| 8 | Introduction to Drug Metabolism | Golan. Chapter 4. C&D. Chapter 6. |
| 9 | Liver Lecture | |
| 10 | Drug Metabolism 2 | Golan. Chapter 4. C&D. Chapter 6. |
| 11 | Drug Metabolism 3 | Golan. Chapter 4. C&D. Chapter 6. |
| 12 | Drug Metabolism 4 | Golan. Chapter 4. C&D. Chapter 6. |
| 13 | Quiz Review | |
| 14 | Oxygen Radicals in Drug Toxicity | |
| 15 | Drug Toxicities | Golan. Chapter 47. |
| 16 | Drug Toxicities (cont.) | Golan. Chapter 47. |
| 17 | Bioethics Seminar | |
| 18 | Pharmacokinetics | Golan. Chapter 3. |
| 19 | Pharmacokinetics (cont.) | Golan. Chapter 3. Farris, F. F., et al. "Cisplatin Pharmacokinetics: Applications of a Physiological Model." Toxicol Lett 43, nos. 1-3 (October 1988): 117-37. Kartalou, M., and J. M. Essigmann. "Recognition of Cisplatin Adducts by Cellular Proteins." Mutat Res 478, nos. 1-2 (July 1, 2001): 1-21. Pinto, A. L., and S. J. Lippard. "Binding of the Antitumor Drug Cis-diamminedichloroplatinum(II) (Cisplatin) to DNA." Biochim Biophys Acta 780, no. 3 (1985): 167-80. |
| 20 | Receptors and Case Study - Omeprazole | Golan. Chapters 1, 2, and 44. de Morais, S. M., et al. "The Major Genetic Defect Responsible for the Polymorphism of S-mephenytoin Metabolism in Humans." J Biol Chem 269, no. 22 (June 3, 1994): 15419-22. Goldstein, J. A. "Clinical Relevance of Genetic Polymorphisms in the Human CYP2C Subfamily." Br J Clin Pharmacol 52, no. 4 (October 2001): 349-55. Kendall, M. J. "Review Article: Esomeprazole - The First Proton Pump Inhibitor to be Developed as an Isomer." Aliment Pharmacol Ther 17, no. 1 (February 2003): 1-4. Lindberg, P., et al. "Review Article: Esomeprazole - Enhanced Bio-availability, Specificity for the Proton Pump and Inhibition of Acid Secretion." Aliment Pharmacol Ther 17, no. 4 (February 15, 2003): 481-8. ———. "The Mechanism of Action of the Gastric Acid Secretion Inhibitor Omeprazole." J Med Chem 29, no. 8 (August 1986): 1327-9. Sachs, G., et al. "The Pharmacology of the Gastric Acid Pump: The H+,K+ ATPase." Annu Rev Pharmacol Toxicol 35 (1995): 277-305. Chang, M., et al. "Interphenotype Differences in Disposition and Effect on Gastrin Levels of Omeprazole - Suitability of Omeprazole as a probe for CYP2C19." BR J Clin Pharmacol 39, no. 5 (May 1995): 511-8. |
| 21 | Case Study - Omeprazole | Golan. Chapter 52. Papers from Lecture 20. |
| 22 | Case Study - Omeprazole (cont.) | Golan. Chapter 52. Papers from Lecture 20. |
| 23 | Case Study - Acetaminophen | Golan. Chapter 40. Hogestatt, E. D., et al. "Conversion of Acetaminophen to the Bioactive N-acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System." J Biol Chem 280, no. 36 (September 9, 2005): 31405-12. Epub (June 29, 2005). Zhang, J., et al. "Modulation of Acetaminophen-induced Hepatotoxicity by the Xenobiotic Receptor CAR." Science 298, no. 5592 (October 11, 2002): 422-4. Sueyoshi, T., et al. "The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene." J Biol Chem 274, no. 10 (March 5, 1999): 6043-6. Knight, T. R., et al. "Peroxynitrite is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by Glutathione." J Pharmacol Exp Ther 303, no. 2 (November 2002): 468-75. |
| 24 | Case Study - Acetaminophen (cont.) | Golan. Chapter 40. Papers from Lecture 23. |
| 25 | Case Study - Statins | Golan. Chapter 22. Zipes, D. P., et al. "Rosuvastatin: An Independent Analysis of Risks and Benefits." MedGenMed 8, no. 73 (2006). Alawi, A., et al. "The Safety of Rosuvastatin as used in Common Clinical Practice." Circulation 111 (2005): 3051-3057. |
| 26 | Case Study - Statins (cont.) | Golan. Chapter 22. Papers from Lecture 25. |
| 27 | Drug Industry Seminar | |
| 28 | Case Study - Statins (cont.) | Golan. Chapter 22. Papers from Lecture 25. |
| 29 | Student Presentations | |
| 30 | Quiz Review | |
| 31 | Student Presentations (cont.) |
Table of Contents
Study Materials
Readings
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A sessionwise listing of readings is included in the table below.
[Golan]: Golan, David E., Editor-in-chief; Armen H. Tashjian, Deputy Editor; Ehrin J. Armstrong, et al., eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Baltimore, MD: Lippincott Williams & Wilkins, 2005. ISBN: 9780781746786.
[C&D]: Klaassen, Curtis D., ed. Casarett and Doull's Toxicology: The Basic Science of Poisons. 6th ed. New York, NY: McGraw-Hill Medical Pub Division, 2001. ISBN: 9780071347211.
Guyton, Arthur C., and John E. Hall. Textbook of Medical Physiology. 11th ed. Philadelphia, PA: Elsevier Saunders, 2005. ISBN: 9780721602400.
Vander, Arthur, James Sherman, and Dorothy Luciano. Human Physiology: The Mechanisms of Body Function. 8th ed. Boston, MA: McGraw-Hill, 2001. ISBN: 9780072554991.
Gilman, A. G., T. W. Rall, A. S. Nies, and P. Taylor, eds. The Pharmacological Basis of Therapeutics. 8th ed. New York, NY: McGraw-Hill, 2000. ISBN: 9780080402963.
Junqueira, Luiz Carlos, José Carneiro, and Robert O. Kelley. Basic Histology. 9th ed. New York, NY: McGraw-Hill, 1998. ISBN: 9780838505908.
Bloom, William, and Don W. Fawcett. A Textbook of Histology. 10th ed. Philadelphia, PA: W.B. Saunders, 1975. ISBN: 9780721617572.