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Medical Artificial Intelligence >> Content Detail



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HST.947 students are expected to complete all readings for 6.034. The Chapter readings assigned for lecture sessions (L) come from the course lecture notes. Additonal readings are assigned for the weekly discussion sessions (D) as listed in the table.


SES #TOPICSREADINGS
D1Organizational Meeting
L1IntroductionChapter 1
R1Scheme Review and Matching
L2SearchChapter 3 (Sec 3.1-3.5)
D2Introduction to Diagnostic ReasoningSzolovits, P., and S. G. Pauker. "Categorical and probabilistic reasoning in medical diagnosis." Artificial Intelligence 11, nos. 1-2 (1978): 115-144.

Pauker, S. G., G. A. Gorry, J. P. Kassirer, and W. B. Schwartz. "Toward the Simulation of Clinical Cognition: Taking the Present Illness." American Journal of Medicine 60 (1976): 1-18.
L3Search (cont.)Chapter 4 (Sec 4.1-4.3)
R2Searches
L4Constraint SatisfactionChapter 5
D3Diagnosis by Pattern Matching and SearchWu, T. D. "Efficient Diagnosis of Multiple Disorders Based on a Symptom Clustering Approach." In Proceedings of the Eighth National Conference on Artificial Intelligence. Menlo Park, CA: AAAI Press, 1990, pp. 357-364.

Amazon logo Pople, H. E., Jr. "Heuristic Methods for Imposing Structure on Ill-Structured Problems: The Structuring of Medical Diagnostics." Chapter 5 in Artificial Intelligence in Medicine. Edited by P. Szolovits. Boulder, CO: Westview Press, 1982, pp. 119-190. ISBN: 9780891589006.
L5GamesChapter 6 (Sec 6.1-6.3)
R3CSP and Games
L6Learning as Search
D4Causal ReasoningSchwartz, W. B., R. S. Patil, and P. Szolovits. "Artificial intelligence in medicine: where do we stand." New England Journal of Medicine 316 (1987): 685-688.

Patil, R. S., P. Szolovits, and W. B. Schwartz. "Causal understanding of patient illness in medical diagnosis." In Proceedings of the Seventh International Joint Conference on Artificial Intelligence, 1981, pp. 893-899.

———. "Information acquisition in diagnosis." In Proceedings of the National Conference on Artificial Intelligence. American Association for Artificial Intelligence, 1982, pp. 345-348.

Patil, R. S. "Causal Representation of Patient Illness for Electrolyte and Acid-Base Diagnosis." MIT Ph.D. Thesis, 1981.
L7Formulating Search
R4Design Project 1
L8Decision TreesChapter 18 (Sec 18.1-18.3)
D5Receiver-Operator Characteristics Curves to Evaluate SystemsLasko, T. A., J. G. Bhagwat, K. H. Zou, and L. Ohno-Machado. The Use of Receiver Operating Characteristic Curves in Biomedical Informatics. (In press.)
L9Naïve BayesChapter 18 (Sec 18.1-18.3)
R5Design Project 1 Presentation and Question-Answer
Q1Quiz 1
D6Prognostic ModelingCooper, Gregory F., et al. "Predicting Dire Outcomes of Patients with Community Acquired Pneumonia." Journal of Biomedical Informatics 38, no. 5 (2005): 347-366.
L10Continuous FeaturesChapter 20 (Sec 20.4)
R6Naïve Bayes and Nearest Neighbor
L11Linear SeparatorsChapter 20 (Sec 20.5-20.6)
D7Classification Methods for Gene Expression DataStatnikov, A., et al. "A comprehensive evaluation of multicategory classification methods for microarray gene expression cancer diagnosis." Bioinformatics 21, no. 5 (2005): 631-643.

Kuo, W. P., et al. "A primer on gene expression and microarrays for machine learning researchers." Journal of Biomedical Informatics 37 (2004): 293–303.
L12Neural NetsChapter 20 (Sec 20.5-20.6)
R7SVM
L13SVMChapter 20 (Sec 20.5-20.6)
D8Predictive ModelsMarcin, J. P., et al. "Combining physician's subjective and physiology-based objective mortality risk predictions." Crit Care Med 28, no. 8 (2000): 2984-90.

Steyerberg, E. W., et al. "Validation and updating of predictive logistic regression models: a study on sample size and shrinkage." Statist Med 23 (2004): 2567-2586.
L14Feature and Model SelectionChapter 20 (Sec 20.5-20.6)
R8Problem Set 6
Q2Quiz 2
D9Learning Medical ReasoningCoderre, S., et al. "Diagnostic reasoning strategies and diagnostic success." Medical Education 37 (2003): 695-703.

Arocha, J. F., et al. "Identifying reasoning strategies in medical decision making: A methodological guide." Journal of Biomedical Informatics (2005 - in press.)
L15Formulating Learning
R9Introduction to Logic
L16Introduction to Logic and Representation
D10PragmaticsHunt, D. L., et al. "Effects of Computer-Based Clinical Decision Support Systems on Physician Performance and Patient Outcomes." JAMA 280, no. 15 (1998): 1339-46.

Kawamoto, K., et al. "Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success." BMJ (British Medical Journal) 330, no. 7494 (2005): 765.

Ammenwerth, E., and N. de Keizer. "An Inventory of Evaluation Studies of Information Technology in Health Care." Methods Inf Med 44 (2005): 44-56.

Nielsen, J. "Medical Usability: How to Kill Patients Through Bad Design."
L17Propositional LogicChapter 7 (Sec 7.1-7.5)
R10Design Project 2 Presentation and Question-Answer
D11Medical Knowledge RepresentationRector, A. L., et al. "The GRAIL Concept Modelling Language for Medical Terminology." Extended version of the paper in Artificial Intelligence in Medicine 9 (1997): 139-171.

Trombert-Paviot, B., et al. "GALEN: a third generation terminology tool to support a multipurpose national coding system for surgical procedures." International Journal of Medical Informatics 58-59 (2000): 71-85.
L18Introduction to Natural Language Processing
R11Logic and Proof
L19First Order LogicChapter 8 (Sec 8.1-8.3)
D12Evaluation of Complex Decision Support SystemsBerner, E. S., et al. "Performance of Four Computer-Based Diagnostic Systems." New England Journal of Medicine 300 (1994): 1792-6.

Fraser, H. S. F., et al. "Evaluation of a Cardiac Diagnostic Program in a Typical Clinical Setting." Journal of the American Medical Informatics Association 10 (2003): 373-381.
L20First Order Logic (cont.)Chapter 9 (Sec 9.1, 9.2, 9.5)
R12Syntax and Semantics
L21RulesChapter 9 (Sec 9.4)
D13Rule-Based Expert SystemsDavis, R., B. G. Buchanan, and E. H. Shortliffe. "Production Rules as a Representation for a Knowledge-Based Consultation Program." Artificial Intelligence 8 (1977): 15-45.

Yu, V. L., B. G. Buchanan, E. H. Shortliffe, S. M. Wraith, R. Davis, A. C. Scott, and S. N. Cohen. "Evaluating the Performance of a Computer-Based Consultant." Comp Programs in Biomedicine 9 (1979): 95-102.

Yu, V. L., et al. "Antimicrobial Selection by a Computer: A Blinded Evaluation by Infectious Diseases Experts." JAMA 242, no. 12 (1979): 1279-82.
L22LanguageChapter 22 (Sec 22.1-22.5)
R13Problem Set 9
L23LanguageChapter 22 (Sec 22.1-22.5)
D14Student Presentations
L24Conclusion
Final Exam

 








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