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Mechanisms of Drug Actions >> Content Detail



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Readings

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A sessionwise listing of readings is included in the table below.



Required Text


[Golan]: Amazon logo Golan, David E., Editor-in-chief; Armen H. Tashjian, Deputy Editor; Ehrin J. Armstrong, et al., eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Baltimore, MD: Lippincott Williams & Wilkins, 2005. ISBN: 9780781746786.



Recommended Text


[C&D]: Amazon logo Klaassen, Curtis D., ed. Casarett and Doull's Toxicology: The Basic Science of Poisons. 6th ed. New York, NY: McGraw-Hill Medical Pub Division, 2001. ISBN: 9780071347211.



Additional Useful Resources


Amazon logo Guyton, Arthur C., and John E. Hall. Textbook of Medical Physiology. 11th ed. Philadelphia, PA: Elsevier Saunders, 2005. ISBN: 9780721602400.

Amazon logo Vander, Arthur, James Sherman, and Dorothy Luciano. Human Physiology: The Mechanisms of Body Function. 8th ed. Boston, MA: McGraw-Hill, 2001. ISBN: 9780072554991.

Amazon logo Gilman, A. G., T. W. Rall, A. S. Nies, and P. Taylor, eds. The Pharmacological Basis of Therapeutics. 8th ed. New York, NY: McGraw-Hill, 2000. ISBN: 9780080402963.

Amazon logo Junqueira, Luiz Carlos, José Carneiro, and Robert O. Kelley. Basic Histology. 9th ed. New York, NY: McGraw-Hill, 1998. ISBN: 9780838505908.

Amazon logo Bloom, William, and Don W. Fawcett. A Textbook of Histology. 10th ed. Philadelphia, PA: W.B. Saunders, 1975. ISBN: 9780721617572.



Readings by Session



LEC #TOPICSREADINGS
1Introduction and Principles
2Chemistry/Biochemistry Review
3Overview of Drug DevelopmentGolan. Chapters 48 and 51.
4Uptake/Transport/Distribution of DrugsGolan. pp. 27-33.
5Drug Transporters
6Bioethics Seminar
7Drug Transporters (cont.)
8Introduction to Drug Metabolism

Golan. Chapter 4.

C&D. Chapter 6.

9Liver Lecture
10Drug Metabolism 2

Golan. Chapter 4.

C&D. Chapter 6.

11Drug Metabolism 3

Golan. Chapter 4.

C&D. Chapter 6.

12Drug Metabolism 4

Golan. Chapter 4.

C&D. Chapter 6.

13Quiz Review
14Oxygen Radicals in Drug Toxicity
15Drug ToxicitiesGolan. Chapter 47.
16Drug Toxicities (cont.)Golan. Chapter 47.
17Bioethics Seminar
18PharmacokineticsGolan. Chapter 3.
19Pharmacokinetics (cont.)

Golan. Chapter 3.

Farris, F. F., et al. "Cisplatin Pharmacokinetics: Applications of a Physiological Model." Toxicol Lett 43, nos. 1-3 (October 1988): 117-37.

Kartalou, M., and J. M. Essigmann. "Recognition of Cisplatin Adducts by Cellular Proteins." Mutat Res 478, nos. 1-2 (July 1, 2001): 1-21.

Pinto, A. L., and S. J. Lippard. "Binding of the Antitumor Drug Cis-diamminedichloroplatinum(II) (Cisplatin) to DNA." Biochim Biophys Acta 780, no. 3 (1985): 167-80.

20Receptors and Case Study - Omeprazole

Golan. Chapters 1, 2, and 44.

de Morais, S. M., et al. "The Major Genetic Defect Responsible for the Polymorphism of S-mephenytoin Metabolism in Humans." J Biol Chem 269, no. 22 (June 3, 1994): 15419-22.

Goldstein, J. A. "Clinical Relevance of Genetic Polymorphisms in the Human CYP2C Subfamily." Br J Clin Pharmacol 52, no. 4 (October 2001): 349-55.

Kendall, M. J. "Review Article: Esomeprazole - The First Proton Pump Inhibitor to be Developed as an Isomer." Aliment Pharmacol Ther 17, no. 1 (February 2003): 1-4.

Lindberg, P., et al. "Review Article: Esomeprazole - Enhanced Bio-availability, Specificity for the Proton Pump and Inhibition of Acid Secretion." Aliment Pharmacol Ther 17, no. 4 (February 15, 2003): 481-8.

———. "The Mechanism of Action of the Gastric Acid Secretion Inhibitor Omeprazole." J Med Chem 29, no. 8 (August 1986): 1327-9.

Sachs, G., et al. "The Pharmacology of the Gastric Acid Pump: The H+,K+ ATPase." Annu Rev Pharmacol Toxicol 35 (1995): 277-305.

Chang, M., et al. "Interphenotype Differences in Disposition and Effect on Gastrin Levels of Omeprazole - Suitability of Omeprazole as a probe for CYP2C19." BR J Clin Pharmacol 39, no. 5 (May 1995): 511-8.

21Case Study - Omeprazole

Golan. Chapter 52.

Papers from Lecture 20.

22Case Study - Omeprazole (cont.)

Golan. Chapter 52.

Papers from Lecture 20.

23Case Study - Acetaminophen

Golan. Chapter 40.

Hogestatt, E. D., et al. "Conversion of Acetaminophen to the Bioactive N-acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System." J Biol Chem 280, no. 36 (September 9, 2005): 31405-12. Epub (June 29, 2005).

Zhang, J., et al. "Modulation of Acetaminophen-induced Hepatotoxicity by the Xenobiotic Receptor CAR." Science 298, no. 5592 (October 11, 2002): 422-4.

Sueyoshi, T., et al. "The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene." J Biol Chem 274, no. 10 (March 5, 1999): 6043-6.

Knight, T. R., et al. "Peroxynitrite is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by Glutathione." J Pharmacol Exp Ther 303, no. 2 (November 2002): 468-75.

24Case Study - Acetaminophen (cont.)

Golan. Chapter 40.

Papers from Lecture 23.

25Case Study - Statins

Golan. Chapter 22.

Zipes, D. P., et al. "Rosuvastatin: An Independent Analysis of Risks and Benefits." MedGenMed 8, no. 73 (2006).

Alawi, A., et al. "The Safety of Rosuvastatin as used in Common Clinical Practice." Circulation 111 (2005): 3051-3057.

26Case Study - Statins (cont.)

Golan. Chapter 22.

Papers from Lecture 25.

27Drug Industry Seminar
28Case Study - Statins (cont.)

Golan. Chapter 22.

Papers from Lecture 25.

29Student Presentations
30Quiz Review
31Student Presentations (cont.)

 








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