Courses:

Biomolecular Kinetics and Cell Dynamics >> Content Detail



Study Materials



Readings

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Instructors


DAL: Prof. Douglas Lauffenburger
FMW: Prof. Forest White
KA: Kathyryn Armstrong
SW: Shan Wu
CR: Craig Rothman



Textbooks


[W&T] Tidor, Bruce, and K. Dane Wittrup. Biological Kinetics.

[L&L] Amazon logo Lauffenburger, Douglas A., and Jennifer Linderman. Models for Binding, Trafficking, and Signaling. New York, NY: Oxford University Press, 1996. ISBN: 9780195106633.


SES #INSTRUCTORSTOPICSREADINGS
L1FMWIntroduction - 20, 20.320, Biology, Mechanisms, and Modeling Protein InteractionsW&T. Chapter 2.
R1KA/SW/CRRecitation 1
L2FMWProtein Interactions II

Thermodynamics of Monovalent Interactions
W&T. Chapter 2, 2.5.2.
L3FMWMonovalent InteractionsW&T. Chapter 3.
R2Recitation 2
L4FMWFractional SaturationW&T. Chapter 3.1-3.2.
L5FMWMeasurement Techniques for Kd
R3KA/SW/CRRecitation 3
L6FMWPerturbations to Monovalent Interactions
L7FMWPerturbations II - Solution Effects
R4Recitation 4
L8FMWMultivalent BindingW&T. Chapter 3.3.
L9FMWCooperativityW&T. Chapter 3.3.2.
R5Recitation 5
L10FMWAvidity and Effective ConcentrationW&T. Chapter 3.3.2.
R6CR/SWRecitation 6
FMWExam 1 - Monovalent Binding, Measurement, Perturbations, Multivalent Binding, Cooperativity
L11FMWEnzyme Kinetics I
L12FMWEnzyme Kinetics II
R7Recitation 7
R8Recitation 8
L13DALEnzyme Inhibitors
L14DALIntegrating Pathways Into Networks
R9Recitation 9
L15DALLigand-Receptor Interactions
L16DALEndocytic Trafficking IL&L. Chapter 3.
R10Recitation 10
R11CR/SWRecitation 11
DAL/FMWExam 2 - Avidity, Enzymes, and Networks
L17DALEndocytic Trafficking IIL&L. Chapter 6.1.3b.
L18DALBiomolecular Reactions in Context of Transport
R12Recitation 12
L19DALFundamentals of Molecular Transport
L20DALReaction Terms and Approximations
R13Recitation 13
L21DALMacroscopic and Microscopic Effects of Diffusion
L22DALAutocrine/Paracrine Cell-cell CommunicationL&L. Chapter 6.1.3c.
R14Recitation 14
L23DALCell Population Dynamics I: Cell Growth, Death, Differentiation, and Product Synthesis
L24DALCell Population Dynamics II: Application to Tissues and Bioreactors
DALExam 3 - Test Accumulated Knowledge (Emphasis on Mechanisms Underlying Biomolecular Systems)

 








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