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Molecular Structure of Biological Materials (BE.442) >> Content Detail



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Lec #TopicsKEY DATES
1Important Role of Water Molecule, Hydration of Amino Acids, Protein and Other Biological Materials
2Amino Acids: Their Chemical and Physical Properties

Influence of Ionic Strength, pH, etc.
3Primary and Secondary Structures of Proteins

Dihedral Angles, Peptide Bonds, Planar Structure, Relationship and Propensity of Amino Acid Sequence, Secondary Structure

Ramachandran Plot
4Alpha-helices, 310 Helix, pi Helix, Beta-helices, etc.

Variation of Helices and Their Helical Bundles, Two Strand Coiled-coils, Three or Four Strand Coiled-coils, Supercoils

Various Helical Rich Protein Structure Models

Alpha-helices in Biological Materials
5Helical Coiled-coils

Two-, Three-, Four- Stranded Helical Bundles

Applying Coiled-coils to Nanomaterials, Molecular Springs, Switches, etc.
6Beta Sheets: Antiparallel, Parallel, and Twist

Beta Sheet Rich Proteins

Beta Sheets in Biological Materials
7Practical Aspects of Single Crystal X-ray Crystallography, Part 1

X-ray Single Crystal Diffraction, Fiber Diffraction

Preparation of the Samples for Diffraction Analyses
8NMR (Guest Lecturer: Peter Carr, MIT Media Lab)
9Practical Aspects of Single Crystal X-ray Crystallography, Part 2
10Analytical Approaches and Instrumentation (Guest Lecturer: Sotirus Koutsopoulos, Ph.D)
11SilkTake-home midterm exam out
12Biomineralization: Sea Creatures
13Biomineralization: Bones and Teeth
14Bioadhesives
15Lipids as Building Materials
16Polysaccharides and Oligosaccharides
17Francis Crick Film
18Molecular Structure and Self-assembly of DNA and RNA
19Macromolecular Interactions and Protein and Adsorption (Guest Lecturer: Larry Unsworth, Ph.D, National Institute for Nanotechnology)

Crystallography (Guest lecturer: Liselotte Kaiser, MIT Center for Biomedical Engineering)
20DNA Molecular MachinesTake-home midterm exam due
21Fluorescent Proteins
22Self-assembling Peptide Systems (Dr. Zhang's Research)
23Self-assembling Peptide Systems (Dr. Zhang's Research) (cont.)

Applying Biomimicry to Nanotechnology (Guest Lecture by Andreas Mershin)
24Research in Biomaterials
25-26Student Research Activity Presentations

 








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