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Analysis of Biological Networks (BE.440) >> Content Detail



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LEC #TOPICS
1Course Introduction

Model networks involved in signaling - Signals that start outside of the cell (role of the ECM) and trigger cascades inside the cell, ultimately affecting gene expression
2Information flow in the reverse direction - from DNA to RNA to protein (the central dogma)

Review of regulatory circuits and introduction to the concept of evolutionary genomics

Key Issues: DNA replication and repair errors lead to mutations. Loss of mismatch repair leads to a hyper-Rec phenotype, which facilitates horizontal gene transfer (antibiotic resistance, etc.)
3Decoding Information I (Transcription Regulation)
4Modeling Macromolecular Structure I

Individual Homework Assignments
5Decoding Information II (Translation)
6Modeling Macromolecular Structure II

Students Present Homework
7Roundtable Discussion
Examination 1
8How to Write an NIH Grant Proposal
9Analysis of the Interferon Network (The JAK/STAT System)
10Analysis of the Interferon Network
11Analysis of the Interferon Network (cont.)
12Analysis of the Interferon Network (cont.)
13Roundtable 1: Students Present Model Projects on Apoptosis
14Chemotaxis I - How Salvage Pathways Supplement Core Biochemical Pathways

The Che System

Receptor Methylation as a Mechanism of Control of Chemotaxis
15Chemotaxis II - How CheY(P) Signals to the Flagellar Motor

Chemiosmotic Coupling

Chemotaxis III. Proton Pumps
16Introduction to the Extracellular Matrix

Roundtable 2 Will be Delayed for a Few Weeks
17Epithelial Cell Morphogenesis Signaling Hierarchy I
18Epithelial Cell Morphogenesis Signaling Hierarchy II
19Round Table Discussion
20Epithelial Cell Morphogenesis Signaling Hierarchy III
Examination 2
21Roundtable 3
22Changes in Lung Epithelium During Pathogenesis I
23Changes in Lung Epithelium During Pathogenesis II
24Network Example: Functional Glycomics
Final Papers Due

 








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