| 1 | Introduction | |
| 2 | The Discovery of RNA Interference | |
| 3 | The Basic Mechanism of RNAi | |
| 4 | Physiological Relevance of the RNAi Pathway | |
| 5 | Short-interfering RNAs (siRNAs) and their Delivery to Cells | |
| 6 | Stable Expression of siRNA: Short Hairpins and Expression Vectors | |
| 7 | Generation of Transgenic Animals for in vivo Silencing | |
| 8 | Field Trip to Mouse-transgenesis Facility | Assignment 1 due |
| 9 | Discussion of First Written Assignment | Choose journal article papers for second assignment |
| 10 | Design of Potent siRNA Sequences | |
| 11 | Large-scale Genetic Analyses Using RNAi | |
| 12 | Student Oral Presentations of their Chosen Papers | Assignment 2 due |
| 13 | Using RNAi in the Prevention of Disease | |
| 14 | Course Summary and Discussion on the Future of RNAi | |